Generalized Baum-Welch algorithm based on the similarity between sequences.

The profile hidden Markov model (PHMM) is widely used to assign the protein sequences to their respective families. A major limitation of a PHMM is the assumption that given states the observations (amino acids) are independent. To overcome this limitation, the dependency between amino acids in a mu...

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Bibliographic Details
Main Authors: Vahid Rezaei, Hamid Pezeshk, Horacio Pérez-Sa'nchez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3869655?pdf=render