Multicentric Standardization of Protocols for the Diagnosis of Human Mitochondrial Respiratory Chain Defects

Multicentric Standardization of Protocols for the Diagnosis of Human Mitochondrial Respiratory Chain Defects

The quantification of mitochondrial respiratory chain (MRC) enzymatic activities is essential for diagnosis of a wide range of mitochondrial diseases, ranging from inherited defects to secondary dysfunctions. MRC lesion is frequently linked to extended cell damage through the generation of proton le...

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Main Authors: Nuria Bujan, Constanza Morén, Francesc J. García-García, Alberto Blázquez, Clara Carnicer, Ana Belén Cortés, Cristina González, Ester López-Gallardo, Ester Lozano, Sonia Moliner, Laura Gort, Ester Tobías, Aitor Delmiro, Miguel Ángel Martin, Miguel Ángel Fernández-Moreno, Eduardo Ruiz-Pesini, Elena Garcia-Arumí, Juan Carlos Rodríguez-Aguilera, Glòria Garrabou
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Antioxidants
Subjects:
mitochondrial respiratory chain
enzyme activity
standardization
diagnosis
mitochondrial disease
Online Access:https://www.mdpi.com/2076-3921/11/4/741

Internet

https://www.mdpi.com/2076-3921/11/4/741

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