Intestinal epithelial glucocorticoid receptor promotes chronic inflammation–associated colorectal cancer

Intestinal epithelial glucocorticoid receptor promotes chronic inflammation–associated colorectal cancer

Synthetic immunosuppressive glucocorticoids (GCs) are widely used to control inflammatory bowel disease (IBD). However, the impact of GC signaling on intestinal tumorigenesis remains controversial. Here, we report that intestinal epithelial GC receptor (GR), but not whole intestinal tissue GR, promo...

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Bibliographic Details
Main Authors: Shuang Tang, Zhan Zhang, Robert H. Oakley, Wenling Li, Weijing He, Xiaojiang Xu, Ming Ji, Qing Xu, Liang Chen, Alicia S. Wellman, Qingguo Li, Leping Li, Jian-Liang Li, Xinxiang Li, John A. Cidlowski, Xiaoling Li
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-12-01
Series:JCI Insight
Subjects:
Gastroenterology
Oncology
Online Access:https://doi.org/10.1172/jci.insight.151815

Internet

https://doi.org/10.1172/jci.insight.151815

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