The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

Summary: p53 regulates multiple signaling pathways and maintains cell homeostasis under conditions of DNA damage and oxidative stress. Although USP7 has been shown to promote p53 stability via deubiquitination, the USP7-p53 activation mechanism has remained unclear. Here, we propose that DNA damage...

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Bibliographic Details
Main Authors: Jingwei Liu, Liangzi Cao, Yubang Wang, Yu Zou, Qiqiang Guo, Shu Chen, Bo Jiang, Xuan Wu, Lixia Zheng, Siyi Zhang, Songming Lu, Keshen Zhou, Pengcheng Jiang, Yutong Xiao, Ruohan Yang, Shiyuan Dong, Ziwei Li, Di Chen, Ying Zhang, Naijin Zhang, Guozhe Sun, Chengzhong Xing, Xiaoyu Song, Zhenning Wang, Liu Cao
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724006946

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http://www.sciencedirect.com/science/article/pii/S2211124724006946

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