IgA Enhances IGF-1 Mitogenic Activity Via Receptor Modulation in Glomerular Mesangial Cells: Implications for IgA-Induced Nephropathy

IgA Enhances IGF-1 Mitogenic Activity Via Receptor Modulation in Glomerular Mesangial Cells: Implications for IgA-Induced Nephropathy

Background/Aim: Glomerulonephritis due to mesangial proliferation is responsible for renal dysfunction in IgA nephropathy (IgAN), however molecular mechanisms of pathogenesis are not well known. We examined the effect of IgA on Insulin-like Growth Factor-1 (IGF-1) activity, a potent mitogen with vit...

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Bibliographic Details
Main Authors: Amal Al-Eisa, Gursev S. Dhaunsi
Format: Article
Language:English
Published: Karger Publishers 2017-06-01
Series:Kidney & Blood Pressure Research
Subjects:
Mesangial cells
IgA
Nephropathy
IGF-1
IGF-1 receptor
Online Access:http://www.karger.com/Article/FullText/478736

Internet

http://www.karger.com/Article/FullText/478736

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