Metformin Preserves VE–Cadherin in Choroid Plexus and Attenuates Hydrocephalus via VEGF/VEGFR2/p-Src in an Intraventricular Hemorrhage Rat Model

Metformin Preserves VE–Cadherin in Choroid Plexus and Attenuates Hydrocephalus via VEGF/VEGFR2/p-Src in an Intraventricular Hemorrhage Rat Model

Hydrocephalus induced by intraventricular hemorrhage (IVH) is associated with unfavorable prognosis. The increased permeability of choroid plexus and breakdown of the blood–brain barrier (BBB) was reported as a prominent mechanism of IVH-induced hydrocephalus, and vascular endothelial–cadherin (VE–c...

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Bibliographic Details
Main Authors: Dan Shen, Xianghua Ye, Jiawen Li, Xiaodi Hao, Luhang Jin, Yujia Jin, Lusha Tong, Feng Gao
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
IVH
hydrocephalus
VE–cadherin
metformin
choroid plexus
VEGF
Online Access:https://www.mdpi.com/1422-0067/23/15/8552

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https://www.mdpi.com/1422-0067/23/15/8552

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