Development of a neutralization monoclonal antibody with a broad neutralizing effect against SARS-CoV-2 variants

Development of a neutralization monoclonal antibody with a broad neutralizing effect against SARS-CoV-2 variants

Abstract Background The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has challenged the effectiveness of current therapeutic regimens. Here, we aimed to develop a potent SARS-CoV-2 antibody with broad neutralizing effect by screening a scFv library with the spik...

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Bibliographic Details
Main Authors: Hae Li Ko, Deuk-ki Lee, Younghyeon Kim, Hui Jeong Jang, Youn Woo Lee, Ho-Young Lee, Sang-Hyuk Seok, Jun Won Park, Jin-Kyung Limb, Da In On, Jun-Won Yun, Kwang-Soo Lyoo, Daesub Song, Minjoo Yeom, Hanbyeul Lee, Je Kyung Seong, Sungjin Lee
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Virology Journal
Subjects:
Severe acute respiratory syndrome coronavirus 2
COVID-19
Antibody
Variant of concern
Human angiotensin-converting enzyme 2
Quaternary epitopes of RBD
Online Access:https://doi.org/10.1186/s12985-023-02230-9

Internet

https://doi.org/10.1186/s12985-023-02230-9

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