2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression

2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression

Background: 2-Methoxyestradiol (2ME), a natural 17-β estradiol metabolite, is a potent anti-inflammatory agent, but its effect on ischemia/reperfusion (IR)-induced acute lung inflammation remains unknown. Annexin A1 (AnxA1), a glucocorticoid-regulated protein, is effective at inhibiting neutrophil t...

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Bibliographic Details
Main Authors: Wen-I Liao, Shu-Yu Wu, Shih-Hung Tsai, Hsin-Ping Pao, Kun-Lun Huang, Shi-Jye Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
2-methoxyestradiol
acute lung injury
ischemia and reperfusion
epithelium
annexin A1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.596376/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.596376/full

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