Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer’s disease and Parkinson’s disease

Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer’s disease and Parkinson’s disease

Abstract Background Degeneration of the locus coeruleus (LC) noradrenergic system contributes to clinical symptoms in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Diffusion magnetic resonance imaging (MRI) has the potential to evaluate the integrity of the LC noradrenergic system. The aim...

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Bibliographic Details
Main Authors: Chen-Pei Lin, Irene Frigerio, John G. J. M. Bol, Maud M. A. Bouwman, Alex J. Wesseling, Martin J. Dahl, Annemieke J. M. Rozemuller, Ysbrand D. van der Werf, Petra J. W. Pouwels, Wilma D. J. van de Berg, Laura E. Jonkman
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Translational Neurodegeneration
Subjects:
Locus coeruleus
Noradrenergic degeneration
Alzheimer’s disease
Parkinson’s disease
Diffusion MRI
Post-mortem
Online Access:https://doi.org/10.1186/s40035-024-00400-5

Internet

https://doi.org/10.1186/s40035-024-00400-5

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