Synthesis and structural analysis of an asymmetric azacyclophane via Mannich cross macrocyclisation of l-tyrosine derivatives

This article describes the synthesis of an asymmetric azacyclophane via a three-component (tyramine, l-tyrosine ethyl ester and formaldehyde) intermolecular hydrogen bond-assisted Mannich reaction.

Bibliographic Details
Main Authors: Laura F. Leal, Sebastián Chaves, Rodolfo Quevedo
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Results in Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622004039