Causality of immune cells on primary sclerosing cholangitis: a bidirectional two-sample Mendelian randomization study

Causality of immune cells on primary sclerosing cholangitis: a bidirectional two-sample Mendelian randomization study

BackgroundObservational studies have indicated that immune dysregulation in primary sclerosing cholangitis (PSC) primarily involves intestinal-derived immune cells. However, the causal relationship between peripheral blood immune cells and PSC remains insufficiently understood.MethodsA bidirectional...

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Bibliographic Details
Main Authors: Pu Wu, Sinan Xie, Yunshi Cai, Hu Liu, Yinghao Lv, Ying Yang, Yucheng He, Bangjie Yin, Tian Lan, Hong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Immunology
Subjects:
primary sclerosing cholangitis (PSC)
Mendelian randomization (MR)
immune cells
genome-wide association study (GWAS)
causal effect
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1395513/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1395513/full

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