Ranolazine Attenuates the Enhanced Reverse Na+-Ca2+ Exchange Current via Inhibiting Hypoxia-Increased Late Sodium Current in Ventricular Myocytes

Ranolazine Attenuates the Enhanced Reverse Na+-Ca2+ Exchange Current via Inhibiting Hypoxia-Increased Late Sodium Current in Ventricular Myocytes

Ranolazine (RAN), a novel antianginal agent, inhibits the increased late sodium current (INa.L) under many pathological conditions. In this study, the whole-cell patch-clamp technique was used to explore the effects of RAN on INa.L and reverse Na+/Ca2+ exchange current (INCX) in rabbit ventricular m...

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Bibliographic Details
Main Authors: Xiao-Jing Wang, Lei-Lei Wang, Chen Fu, Pei-Hua Zhang, Ying Wu, Ji-Hua Ma
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319301872

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http://www.sciencedirect.com/science/article/pii/S1347861319301872

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