Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and pain

Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and pain

Abstract Background Paclitaxel is a widely prescribed chemotherapy drug for treating solid tumors. However, paclitaxel-induced peripheral neuropathy (PIPN) is a common adverse effect during paclitaxel treatment, which results in sensory abnormalities and neuropathic pain among patients. Unfortunatel...

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Bibliographic Details
Main Authors: Yuanyuan Li, Chengyu Yin, Boyu Liu, Huimin Nie, Jie Wang, Danyi Zeng, Ruixiang Chen, Xiaofen He, Junfan Fang, Junying Du, Yi Liang, Yongliang Jiang, Jianqiao Fang, Boyi Liu
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Neuroinflammation
Subjects:
RNA-Seq
LncRNA
Paclitaxel
Neuropathic pain
Inflammation
Online Access:https://doi.org/10.1186/s12974-021-02098-y

Internet

https://doi.org/10.1186/s12974-021-02098-y

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