Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.

The causative agent of Legionnaires' disease, Legionella pneumophila, uses the Icm/Dot type IV secretion system (T4SS) to form in phagocytes a distinct "Legionella-containing vacuole" (LCV), which intercepts endosomal and secretory vesicle trafficking. Proteomics revealed the presence...

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Bibliographic Details
Main Authors: Eva Rothmeier, Gudrun Pfaffinger, Christine Hoffmann, Christopher F Harrison, Heinrich Grabmayr, Urska Repnik, Mandy Hannemann, Stefan Wölke, Andreas Bausch, Gareth Griffiths, Annette Müller-Taubenberger, Aymelt Itzen, Hubert Hilbi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3777869?pdf=render

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http://europepmc.org/articles/PMC3777869?pdf=render

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