Clinical Efficacy of Cortex Daphnes (Zushima) Patch in Patients With Symptomatic Knee Osteoarthritis: A Multicenter Non-Inferiority Randomized Controlled Clinical Trial

Clinical Efficacy of Cortex Daphnes (Zushima) Patch in Patients With Symptomatic Knee Osteoarthritis: A Multicenter Non-Inferiority Randomized Controlled Clinical Trial

Background: Osteoarthritis (OA) is imposing substantial burdens on individuals and society with the aging population. Cortex Daphnes patch is widely used for symptomatic knee OA in China with a satisfying clinical efficacy; however, there is scant clinical evidence supporting its use. To evaluate it...

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Bibliographic Details
Main Authors: Yan-Ting Li, Juan Jiao, Yi Zhang, Ci-Bo Huang, Hai-Dong Wang, Bei Wang, Xiao Su, Hui Song, Mian-Song Zhao, De-Xun Jiang, Jia-Qiang Wang, Quan Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
knee osteoarthritis
nonsteroidal anti-inflammatory drugs
Cortex Daphnes patch
pain
non-inferiority trial design
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.646310/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.646310/full

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