Phenotyping of FGF12AV52H mutation in mouse implies a complex FGF12 network

Phenotyping of FGF12AV52H mutation in mouse implies a complex FGF12 network

Pathogenic missense mutation of the FGF12 gene is responsible for a variable disease phenotypic spectrum. Disease-specific therapies require precise dissection of the relationship between different mutations and phenotypes. The lack of a proper animal model hinders the investigation of related disea...

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Bibliographic Details
Main Authors: Jianyu Huang, Chongyang Sun, Qian Zhu, Ge Wu, Yi Cao, Jiarui Shi, Shuyu He, Luyao Jiang, Jianxiang Liao, Lin Li, Cheng Zhong, Yi Lu
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Neurobiology of Disease
Subjects:
FGF12A
Hippocampus
Seizure susceptibility
Cognition deficit
Excitatory/inhibitory balance
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124002377

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http://www.sciencedirect.com/science/article/pii/S0969996124002377

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