Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress

Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress

Abstract Background Tumor cells display augmented capability to maintain endoplasmic reticulum (ER) homeostasis and hijack ER stress pathway for malignant phenotypes under microenvironmental stimuli. Metabolic reprogramming is a well-known hallmark for tumor cells to provide specific adaptive traits...

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Bibliographic Details
Main Authors: Chenyu Hu, Zechang Xin, Xiaoyan Sun, Yang Hu, Chunfeng Zhang, Rui Yan, Yuying Wang, Min Lu, Jing Huang, Xiaojuan Du, Baocai Xing, Xiaofeng Liu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ER stress
Metabolic reprogramming
Hepatocellular carcinoma
Metastasis
ACLY
SEC63
Online Access:https://doi.org/10.1186/s13046-023-02656-7

Internet

https://doi.org/10.1186/s13046-023-02656-7

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