Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation

The mechanistic target of the rapamycin (mTOR) pathway, which participates in the regulation of cellular growth and metabolism, is aberrantly regulated in various cancer types. The mTOR complex 2 (mTORC2), which consists of the core components mTOR, Rictor, mSin1, and mLST8, primarily responds to gr...

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Bibliographic Details
Main Authors: Yingji Chen, Dongyue Jiao, Huiying He, Huiru Sun, Yajuan Liu, Qing Shi, Pingzhao Zhang, Yao Li, Ren Mo, Kun Gao, Chenji Wang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Redox Biology
Subjects:
mTORC2
AKT
Keap1
ROS
Ubiquitination
Lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002732

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http://www.sciencedirect.com/science/article/pii/S2213231723002732

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