Transplantation, gene therapy and intestinal pathology in MNGIE patients and mice

Transplantation, gene therapy and intestinal pathology in MNGIE patients and mice

Abstract Background Gastrointestinal complications are the main cause of death in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Available treatments often restore biochemical homeostasis, but fail to cure gastrointestinal symptoms. Methods We evaluated the small intest...

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Bibliographic Details
Main Authors: Rana Yadak, Max V. Boot, Niek P. van Til, Dominique Cazals-Hatem, Armin Finkenstedt, Elly Bogaerts, Irenaeus F. de Coo, Marianna Bugiani
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Gastroenterology
Subjects:
Mitochondrial neurogastrointestinal encephalomyopathy
Gastrointestinal symptoms
HSCT
HCSGT
Hematopoietic stem cell gene therapy
Cajal cells
Online Access:http://link.springer.com/article/10.1186/s12876-018-0881-0

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http://link.springer.com/article/10.1186/s12876-018-0881-0

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