Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that th...

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Bibliographic Details
Main Authors: Jason D Plummer, Spike DL Postnikoff, Jessica K Tyler, Jay E Johnson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/62483