Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/62483 |
| _version_ | 1811201503134744576 |
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| author | Jason D Plummer Spike DL Postnikoff Jessica K Tyler Jay E Johnson |
| author_facet | Jason D Plummer Spike DL Postnikoff Jessica K Tyler Jay E Johnson |
| author_sort | Jason D Plummer |
| collection | DOAJ |
| description | Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that interventions that decrease IGF-1 signaling would also produce MR-like healthspan benefits. Selenium supplementation inhibits IGF-1 signaling in rats and has been studied for its putative healthspan benefits. Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin. Selenomethionine supplementation results in a similar, albeit less robust response, and also extends budding yeast lifespan. Our results indicate that selenium supplementation is sufficient to produce MR-like healthspan benefits for yeast and mammals. |
| first_indexed | 2024-04-12T02:22:45Z |
| format | Article |
| id | doaj.art-d086dd1cdb924744b92596e79bdf10b9 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:22:45Z |
| publishDate | 2021-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d086dd1cdb924744b92596e79bdf10b92022-12-22T03:52:05ZengeLife Sciences Publications LtdeLife2050-084X2021-03-011010.7554/eLife.62483Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to miceJason D Plummer0Spike DL Postnikoff1Jessica K Tyler2https://orcid.org/0000-0001-9765-1659Jay E Johnson3https://orcid.org/0000-0002-1267-7575Department of Biology, Orentreich Foundation for the Advancement of Science, Cold Spring, United StatesDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United StatesDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United StatesDepartment of Biology, Orentreich Foundation for the Advancement of Science, Cold Spring, United StatesMethionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that interventions that decrease IGF-1 signaling would also produce MR-like healthspan benefits. Selenium supplementation inhibits IGF-1 signaling in rats and has been studied for its putative healthspan benefits. Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as altered plasma levels of IGF-1, FGF-21, adiponectin, and leptin. Selenomethionine supplementation results in a similar, albeit less robust response, and also extends budding yeast lifespan. Our results indicate that selenium supplementation is sufficient to produce MR-like healthspan benefits for yeast and mammals.https://elifesciences.org/articles/62483aginglifespanmetabolismmitophagyselenomethioninehistone deacetylase |
| spellingShingle | Jason D Plummer Spike DL Postnikoff Jessica K Tyler Jay E Johnson Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice eLife aging lifespan metabolism mitophagy selenomethionine histone deacetylase |
| title | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
| title_full | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
| title_fullStr | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
| title_full_unstemmed | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
| title_short | Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice |
| title_sort | selenium supplementation inhibits igf 1 signaling and confers methionine restriction like healthspan benefits to mice |
| topic | aging lifespan metabolism mitophagy selenomethionine histone deacetylase |
| url | https://elifesciences.org/articles/62483 |
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