Influence of Polymorphism −308 G/A of the Tnf-α Gene on High Mobility Group Box-1 Protein in Rheumatoid and Spondylo-Arthritis Patients

Influence of Polymorphism −308 G/A of the Tnf-α Gene on High Mobility Group Box-1 Protein in Rheumatoid and Spondylo-Arthritis Patients

Single nucleotide polymorphism (SNP) in the human Tumor Necrosis Factor-α(TNF-α) gene promoter, the −308 G/A variant, has been associated with increased TNF-α levels that may amplify the severity of rheumatoid arthritis (RA) and a poor responsiveness to TNF-α blockade therapy. High mobility group bo...

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Bibliographic Details
Main Authors: A. Bitto, F. Polito, G. Bagnato, R. Talotta, M. Atteritano, N. Irrera, R. Ientile, N. Ferlazzo, D. Caccamo, A. Caliri, F. Squadrito, D. Altavilla
Format: Article
Language:English
Published: SAGE Publishing 2012-09-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/1721727X1201000316

Internet

https://doi.org/10.1177/1721727X1201000316

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