SPECT Imaging of SST2-Expressing Tumors with <sup>99m</sup>Tc-Based Somatostatin Receptor Antagonists: The Role of Tetraamine, HYNIC, and Spacers

SPECT Imaging of SST2-Expressing Tumors with <sup>99m</sup>Tc-Based Somatostatin Receptor Antagonists: The Role of Tetraamine, HYNIC, and Spacers

[<sup>99m</sup>Tc]Tc-HYNIC-TOC is the most widely used <sup>99m</sup>Tc-labeled somatostatin receptor (SST) agonist for the SPECT imaging of SST-expressing tumors, such as neuroendocrine tumors. Recently, radiolabeled SST antagonists have shown improved diagnostic efficacy ov...

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Bibliographic Details
Main Authors: Raghuvir Haridas Gaonkar, Fabius Wiesmann, Luigi Del Pozzo, Lisa McDougall, Sandra Zanger, Renata Mikołajczak, Rosalba Mansi, Melpomeni Fani
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
<sup>99m</sup>Tc
SPECT/CT
HYNIC
N4
aminohexanoic acid
spacer
Online Access:https://www.mdpi.com/1424-8247/14/4/300

Internet

https://www.mdpi.com/1424-8247/14/4/300

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