Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal epithelial mesenchymal transition and fibrosis

Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal epithelial mesenchymal transition and fibrosis

AIM: To evaluate the effect of exogenous recombinant human bone morphogenic protein-7 (rhBMP-7) on transforming growth factor-β (TGF-β)-induced epithelial mesenchymal cell transition (EMT) and assessed its antifibrotic effect via topical application. METHODS: The cytotoxic effect of rhBMP-7 was eva...

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Bibliographic Details
Main Authors: Jin Kwon Chung, Shin Ae Park, Hee Sun Hwang, Kwang Sung Kim, Yang Je Cho, Yong Sung You, Young Sik Kim, Ju Woong Jang, Sung Jin Lee
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2017-03-01
Series:International Journal of Ophthalmology
Subjects:
bone morphogenic protein-7
corneal fibrosis
epithelial mesenchymal transition
myodifferentiation
transforming growth factor-β
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360764/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360764/

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