Evolution of Conformation, Nanomechanics, and Infrared Nanospectroscopy of Single Amyloid Fibrils Converting into Microcrystals

Evolution of Conformation, Nanomechanics, and Infrared Nanospectroscopy of Single Amyloid Fibrils Converting into Microcrystals

Abstract Nanomechanical properties of amyloid fibrils and nanocrystals depend on their secondary and quaternary structure, and the geometry of intermolecular hydrogen bonds. Advanced imaging methods based on atomic force microscopy (AFM) have unravelled the morphological and mechanical heterogeneity...

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Bibliographic Details
Main Authors: Jozef Adamcik, Francesco Simone Ruggeri, Joshua T. Berryman, Afang Zhang, Tuomas P. J. Knowles, Raffaele Mezzenga
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Advanced Science
Subjects:
amyloid crystals
amyloid fibrils
amyloid polymorphism
nanomechanical properties
secondary structure
Online Access:https://doi.org/10.1002/advs.202002182

Internet

https://doi.org/10.1002/advs.202002182

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