The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media

The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media

Otitis media (OM) is a leading cause of childhood hearing loss. Variants in FUT2, which encodes alpha-(1,2)-fucosyltransferase, were identified to increase susceptibility to OM, potentially through shifts in the middle ear (ME) or nasopharyngeal (NP) microbiotas as mediated by transcriptional change...

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Bibliographic Details
Main Authors: Christina L. Elling, Melissa A. Scholes, Sven-Olrik Streubel, Eric D. Larson, Todd M. Wine, Tori C. Bootpetch, Patricia J. Yoon, Jennifer M. Kofonow, Samuel P. Gubbels, Stephen P. Cass, Charles E. Robertson, Herman A. Jenkins, Jeremy D. Prager, Daniel N. Frank, Kenny H. Chan, Norman R. Friedman, Allen F. Ryan, Regie Lyn P. Santos-Cortez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
FUT2
microbiota
otitis media
p.Trp154*
RNA-sequencing
rs601338
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.798246/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.798246/full

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