TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome translocations from DSBs introduced during ge...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00307-y |