Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production

Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production

Increased glucocorticoid (GC) levels act as a master contributor to central obesity in estrogen-depleted females; however, what factors cause their increased GC production is unclear. Given (1) liver fibroblast growth factor 21 (FGF21) and GCs regulate each other’s production in a feed-forward loop,...

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Bibliographic Details
Main Authors: Jiayu Xu, Xinyu Shao, Haozhe Zeng, Chengxi Wang, Jiayi Li, Xiaoqin Peng, Yong Zhuo, Lun Hua, Fengyan Meng, Xingfa Han
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
FGF21
overiectomy
central obesity
corticosterone
insulin
metabolic syndromes
Online Access:https://www.mdpi.com/1422-0067/24/19/14922

Internet

https://www.mdpi.com/1422-0067/24/19/14922

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