Novel Triterpenoids from <i>Cassia fistula</i> Stem Bark Depreciates STZ-Induced Detrimental Changes in IRS-1/Akt-Mediated Insulin Signaling Mechanisms in Type-1 Diabetic Rats

Novel Triterpenoids from <i>Cassia fistula</i> Stem Bark Depreciates STZ-Induced Detrimental Changes in IRS-1/Akt-Mediated Insulin Signaling Mechanisms in Type-1 Diabetic Rats

Here, we identified the mechanisms of action of antidiabetic activity of novel compounds isolated from <i>Cassia fistula</i> stem bark in STZ-diabetic animals. Novel triterpenoid compounds (C1, C2 and C3) were treated to STZ-administered diabetic animals at a concentration of 20mg/kg bod...

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Bibliographic Details
Main Authors: Sabapathy Indu, Periyasamy Vijayalakshmi, Jayaraman Selvaraj, Manikkam Rajalakshmi
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
<i>Cassia fistula</i>
novel triterpenoids
diabetes mellitus
insulin signaling
in vivo
in silico
Online Access:https://www.mdpi.com/1420-3049/26/22/6812

Internet

https://www.mdpi.com/1420-3049/26/22/6812

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