Mutated Flt3Lg Provides Reduced Flt3 Recycling Compared to Wild-Type Flt3Lg and Retains the Specificity of Flt3Lg-Based CAR T-Cell Targeting in AML Models

Mutated Flt3Lg Provides Reduced Flt3 Recycling Compared to Wild-Type Flt3Lg and Retains the Specificity of Flt3Lg-Based CAR T-Cell Targeting in AML Models

The cells of acute myeloid leukemia are defined by clonal growth and heterogenous immunophenotypes. Chimeric antigen receptors (CARs) commonly recognize molecular targets by single-chain antibody fragments (scFvs) specific to a tumor-associated antigen. However, ScFvs may form aggregates, thus stimu...

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Bibliographic Details
Main Authors: Varvara Maiorova, Murad D. Mollaev, Polina Vikhreva, Dmitriy M. Chudakov, Alexey Kibardin, Michael A. Maschan, Sergey Larin
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
ligand-based targeting
acute myeloid leukemia
natural-ligand chimeric antigen receptor (CAR) T
fms-like tyrosine kinase 3 (Flt3)
fms-like tyrosine kinase 3 ligand variant (Flt3Lg-L27P) bioactivity
Online Access:https://www.mdpi.com/1422-0067/24/8/7626

Internet

https://www.mdpi.com/1422-0067/24/8/7626

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