Pharmacologic Antagonization of Cannabinoid Receptor 1 Improves Cholestasis in Abcb4-/- MiceSummary

Pharmacologic Antagonization of Cannabinoid Receptor 1 Improves Cholestasis in Abcb4-/- MiceSummary

Background & Aims: The endocannabinoid system is involved in the modulation of inflammatory, fibrotic, metabolic, and carcinogenesis-associated signaling pathways via cannabinoid receptor (CB)1 and CB2. We hypothesized that the pharmacologic antagonization of CB1 receptor improves cholestasi...

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Bibliographic Details
Main Authors: Nora Helmrich, Martin Roderfeld, Anne Baier, Anita Windhorst, Diran Herebian, Ertan Mayatepek, Christian Dierkes, Matthias Ocker, Dieter Glebe, Bruno Christ, Yuri Churin, Karuna Irungbam, Elke Roeb
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Liver
Rimonabant
Bile Acid
Acute Phase
Fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21002630

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X21002630

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