Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury

Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury

Backgroud: Ferroptosis is a form of regulated cell death in ischemia-reperfusion (I/R) injury models. Acute kidney injury (AKI) induced by I/R injury can result in cell death, and subcellular structural changes, including expansion of the endoplasmic reticulum (ER), mitochondrial shrinkage, and othe...

Full description

Bibliographic Details
Main Authors: Yan Liang, Zhenjie Liu, Lingyun Qu, Yingzi Wang, Yali Zhou, Lulu Liang, Yanhong Guo, Lin Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
AKI (acute kidney injury)
IRE1 (inositol-requiring enzyme 1)
JNK (c-Jun N-terminal kinase)
ferroptosis
ER stress
tubular epithelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.927641/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.927641/full

Similar Items