The exploration of the potential mechanism of oxymatrine-mediated antipruritic effect based on network pharmacology and weighted gene co-expression network analysis

The treatment of chronic itch is considered to be a challenge for its non-histamine dependence and the search for alternative medicine is still striving. The pathology of the chronic itch is closely related to immune system regulation and inflammatory response. Oxymatrine (OMT) is a traditional Chin...

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Bibliographic Details
Main Authors: Zhenhui Luo, Tingting Zhao, Mengqin Yi, Tingting Wang, Zhenglang Zhang, Wenbin Li, Na Lin, Shangdong Liang, Alexei Verkhratsky, Hong Nie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.946602/full