Temperature Upshifts in Mammalian Cell Culture: A Suitable Strategy for Biosimilar Monoclonal Antibodies?

Temperature Upshifts in Mammalian Cell Culture: A Suitable Strategy for Biosimilar Monoclonal Antibodies?

Temperature downshifts are the gold standard when setting up control strategies for mammalian cell culture processes. These shifts are performed to prolong production phases and attain heightened levels of productivity. For the development of biosimilars, however, the bottleneck is in achieving a pr...

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Bibliographic Details
Main Authors: Lukas Marschall, Chitti Babu Gottimukkala, Biswajit Kayal, Veerabhadra Madurai Veeraraghavan, Samir Kumar Mandal, Suman Bandyopadhyay, Christoph Herwig
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Bioengineering
Subjects:
biosimilar
mammalian cell culture
temperature downshift
scale-up
Online Access:https://www.mdpi.com/2306-5354/10/10/1149

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https://www.mdpi.com/2306-5354/10/10/1149

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