Fully Attenuated meq and pp38 Double Gene Deletion Mutant Virus Confers Superior Immunological Protection against Highly Virulent Marek’s Disease Virus Infection

Fully Attenuated meq and pp38 Double Gene Deletion Mutant Virus Confers Superior Immunological Protection against Highly Virulent Marek’s Disease Virus Infection

ABSTRACT Marek’s disease virus (MDV) induces immunosuppression and neoplastic disease in chickens. The virus is controllable via an attenuated meq deletion mutant virus, which has the disadvantage of retaining the ability to induce lymphoid organ atrophy. To overcome this deficiency and produce more...

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Bibliographic Details
Main Authors: Aijun Sun, Xuyang Zhao, Xiaojing Zhu, Zhengjie Kong, Yifei Liao, Man Teng, Yongxiu Yao, Jun Luo, Venugopal Nair, Guoqing Zhuang, Gaiping Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
Marek’s disease virus
meq
lymphoid organ atrophy
pp38
gene deletion
vaccine
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02871-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02871-22

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