Circulating mitochondrial DNA promotes M2 polarization of tumor associated macrophages and HCC resistance to sorafenib

Circulating mitochondrial DNA promotes M2 polarization of tumor associated macrophages and HCC resistance to sorafenib

Abstract Mitochondrial damage-associated molecular patterns (DAMPs) including mitochondrial DNA (mtDNA), TFAM (transcription factor A, mitochondrial), and ATP, which play crucial roles in the regulation of inflammatory environment in human diseases. However, the role of mitochondrial DAMPs in regula...

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Bibliographic Details
Main Authors: Qi Yang, Mengmeng Cui, Jiaxin Wang, Yuan Zhao, Weitao Yin, Ziqian Liao, Yixuan Liang, Zhixiong Jiang, Yujia Li, Jinrong Guo, Lixia Qi, Jiaxing Chen, Jing Zhao, Dengke Bao, Zhi-Xiang Xu
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07473-8

Internet

https://doi.org/10.1038/s41419-025-07473-8

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