Design and Synthesis of Various 5′-Deoxy-5′-(4-Substituted-1,2,3-Triazol-1-yl)-Uridine Analogues as Inhibitors of <i>Mycobacterium tuberculosis</i> Mur Ligases

Design and Synthesis of Various 5′-Deoxy-5′-(4-Substituted-1,2,3-Triazol-1-yl)-Uridine Analogues as Inhibitors of <i>Mycobacterium tuberculosis</i> Mur Ligases

The synthesis of hitherto unknown 5′-deoxy-5′-(4-substituted-1,2,3-triazol-1-yl)-uridine and its evaluation, through an one-pot screening assay, against MurA-F enzymes involved in <i>Mycobacterium tuberculosis</i> (Mtb), are described. Starting from UDP-<i>N</i>-acetylmuramic...

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Bibliographic Details
Main Authors: Vincent Hervin, Ritu Arora, Jyoti Rani, Srinivasan Ramchandran, Urmi Bajpai, Luigi A. Agrofoglio, Vincent Roy
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
Mur ligase
nucleoside analogues
copper-catalyzed azide-alkyne cycloaddition
antibacterial agents
molecular modelling
Online Access:https://www.mdpi.com/1420-3049/25/21/4953

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https://www.mdpi.com/1420-3049/25/21/4953

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