Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak

Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak

Mitochondrial permeability transition pore (MPTP)-dependent necrosis contributes to numerous pathologies in the heart, brain, and skeletal muscle. The MPTP is a non-selective pore in the inner mitochondrial membrane that is triggered by high levels of matrix Ca2+, and sustained opening leads to mito...

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Bibliographic Details
Main Authors: Pooja Patel, Arielys Mendoza, Dexter J. Robichaux, Meng C. Wang, Xander H. T. Wehrens, Jason Karch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mitochondria
permeability transition
BCL-2 family
BH3 mimetics
necrosis
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.765973/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.765973/full

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