Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networks

Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networks

Abstract Background Sitting at the interface of gene expression and host-pathogen interaction, polymerase associated factor 1 complex (PAF1C) is a rising player in the innate immune response. The complex localizes to the nucleus and associates with chromatin to modulate RNA polymerase II (RNAPII) el...

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Bibliographic Details
Main Authors: Matthew W. Kenaston, Oanh H. Pham, Marine J. Petit, Priya S. Shah
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Genomics
Subjects:
Polymerase associated factor 1 complex (PAF1C)
Innate immunity
Network analysis
Gene expression
Transcriptomics
Regulatory motifs
Online Access:https://doi.org/10.1186/s12864-022-09013-6

Internet

https://doi.org/10.1186/s12864-022-09013-6

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