MicroRNA exporter HuR clears the internalized pathogens by promoting pro‐inflammatory response in infected macrophages

MicroRNA exporter HuR clears the internalized pathogens by promoting pro‐inflammatory response in infected macrophages

Abstract HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to negate their action on target mRNAs. Here we have identified how HuR, by inducing extracellular vesicles‐mediated export of miRNAs, ensures robust derepression of miRNA‐repressed cytokines essential for s...

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Bibliographic Details
Main Authors: Avijit Goswami, Kamalika Mukherjee, Anup Mazumder, Satarupa Ganguly, Ishita Mukherjee, Saikat Chakrabarti, Syamal Roy, Shyam Sundar, Krishnananda Chattopadhyay, Suvendra N Bhattacharyya
Format: Article
Language:English
Published: Springer Nature 2020-03-01
Series:EMBO Molecular Medicine
Subjects:
Ago2 dephosphorylation
drug‐resistant Leishmania
host–parasite interaction
miRNA export
protein phosphatase 2A
Online Access:https://doi.org/10.15252/emmm.201911011

Internet

https://doi.org/10.15252/emmm.201911011

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