HIV-1 Integrase Inhibition Activity by Spiroketals Derived from <i>Plagius flosculosus</i>, an Endemic Plant of Sardinia (Italy) and Corsica (France)

HIV-1 Integrase Inhibition Activity by Spiroketals Derived from <i>Plagius flosculosus</i>, an Endemic Plant of Sardinia (Italy) and Corsica (France)

In this work we investigated, for the first time, the effect of <i>Plagius flosculosus</i> (L.) Alavi & Heywood, a Sardinian–Corsican endemic plant, on HIV-1 integrase (IN) activity. The phytochemical analysis of the leaves chloroform extract led us to isolate and characterize three...

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Bibliographic Details
Main Authors: Cinzia Sanna, Brigida D’Abrosca, Antonio Fiorentino, Federica Giammarino, Ilaria Vicenti, Angela Corona, Alessia Caredda, Enzo Tramontano, Francesca Esposito
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceuticals
Subjects:
<i>Plagius flosculosus</i>
<sup>1</sup>H-NMR profiling
spiroketals
HIV-1 inhibitors
integrase
IN-LEDGF binding inhibitors
Online Access:https://www.mdpi.com/1424-8247/16/8/1118

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https://www.mdpi.com/1424-8247/16/8/1118

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