Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP

Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP

3′,5′-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ribozyme activity consisting of terminal ligatio...

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Bibliographic Details
Main Authors: Samanta Pino, Giovanna Costanzo, Alessandra Giorgi, Jiří Šponer, Judit E. Šponer, Ernesto Di Mauro
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Entropy
Subjects:
RNA
RNA polymerization
RNA origin
ribozymes
origin of life
Online Access:http://www.mdpi.com/1099-4300/15/12/5362

Internet

http://www.mdpi.com/1099-4300/15/12/5362

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