Homocysteine metabolites inhibit autophagy by upregulating miR-21-5p, miR-155-5p, miR-216-5p, and miR-320c-3p in human vascular endothelial cells

Homocysteine metabolites inhibit autophagy by upregulating miR-21-5p, miR-155-5p, miR-216-5p, and miR-320c-3p in human vascular endothelial cells

Abstract Nutritional and genetic deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis, which is a major cause of cardiovascular disease (CVD). Impaired autophagy causes the accumulation of damaged proteins...

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Bibliographic Details
Main Authors: Łukasz Witucki, Hieronim Jakubowski
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Homocysteine metabolites
microRNA
Autophagy
Endothelial dysfunction
HUVEC
Online Access:https://doi.org/10.1038/s41598-024-57750-3

Internet

https://doi.org/10.1038/s41598-024-57750-3

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