Intra-Articular Lactate Dehydrogenase A Inhibitor Oxamate Reduces Experimental Osteoarthritis and Nociception in Rats via Possible Alteration of Glycolysis-Related Protein Expression in Cartilage Tissue

Intra-Articular Lactate Dehydrogenase A Inhibitor Oxamate Reduces Experimental Osteoarthritis and Nociception in Rats via Possible Alteration of Glycolysis-Related Protein Expression in Cartilage Tissue

Osteoarthritis (OA) is the most common form of arthritis and joint disorder worldwide. Metabolic reprogramming of osteoarthritic chondrocytes from oxidative phosphorylation to glycolysis results in the accumulation of lactate from glycolytic metabolite pyruvate by lactate dehydrogenase A (LDHA), lea...

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Bibliographic Details
Main Authors: Zhi-Hong Wen, Chun-Sung Sung, Sung-Chun Lin, Zhi-Kang Yao, Yu-Cheng Lai, Yu-Wei Liu, Yu-Yan Wu, Hsi-Wen Sun, Hsin-Tzu Liu, Wu-Fu Chen, Yen-Hsuan Jean
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis
oxamate
glycolysis
chondrocytes
lactate dehydrogenase A
Online Access:https://www.mdpi.com/1422-0067/24/13/10770

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https://www.mdpi.com/1422-0067/24/13/10770

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