Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children

Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children

An expression-based polygenic risk score analysis of leptin receptor (LepR) genes suggests that LepR-specific genes co-expressed in the prefrontal cortex interact with exposure to postnatal adversity, potentially modulating eating behavior in children.

Bibliographic Details
Main Authors: Randriely Merscher Sobreira de Lima, Barbara Barth, Danusa Mar Arcego, Euclides José de Mendonça Filho, Sachin Patel, Zihan Wang, Irina Pokhvisneva, Carine Parent, Robert D. Levitan, Michael S. Kobor, Ana Paula Santana de Vasconcellos Bittencourt, Michael J. Meaney, Carla Dalmaz, Patrícia Pelufo Silveira
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03992-8

Internet

https://doi.org/10.1038/s42003-022-03992-8

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