Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR

Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR

Severe acute pancreatitis (SAP) is a lethal gastrointestinal disorder, yet no specific and effective treatment is available. Its pathogenesis involves inflammatory cascade, oxidative stress, and autophagy dysfunction. Xanthohumol (Xn) displays various medicinal properties,including anti-inflammation...

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Bibliographic Details
Main Authors: Yaru Huangfu, Xiuxian Yu, Chengyu Wan, Yuda Zhu, Zeliang Wei, Fan Li, Yilan Wang, Kun Zhang, Shiyi Li, Yuman Dong, Yangying Li, Hai Niu, Guang Xin, Wen Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
acute pancreatitis
xanthohumol
autophagy
inflammation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1105726/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1105726/full

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