A novel MDSC-induced PD-1−PD-L1+ B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties

A novel MDSC-induced PD-1−PD-L1+ B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that suppress T-cell activity in a tumor microenvironment. However, the suppressive function of MDSCs on B cells and its underlying mechanism remain unclear. Here, we show that in 4T1 breast cancer mice, a significan...

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Bibliographic Details
Main Authors: Meng Shen, Jian Wang, Wenwen Yu, Chen Zhang, Min Liu, Kaiyuan Wang, Lili Yang, Feng Wei, Shizhen Emily Wang, Qian Sun, Xiubao Ren
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:OncoImmunology
Subjects:
breast cancer
pd-1/pd-l1 axis
mdsc
regulatory b cells
tumor immunity
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1413520

Internet

http://dx.doi.org/10.1080/2162402X.2017.1413520

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