Optimizing aspirin dose for colorectal cancer patients through deep phenotyping using novel biomarkers of drug action

Optimizing aspirin dose for colorectal cancer patients through deep phenotyping using novel biomarkers of drug action

Background: Low-dose aspirin’s mechanism of action for preventing colorectal cancer (CRC) is still debated, and the optimal dose remains uncertain. We aimed to optimize the aspirin dose for cancer prevention in CRC patients through deep phenotyping using innovative biomarkers for aspirin’s action.Me...

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Bibliographic Details
Main Authors: Paola Patrignani, Stefania Tacconelli, Annalisa Contursi, Elena Piazuelo, Annalisa Bruno, Stefania Nobili, Matteo Mazzei, Cristina Milillo, Ulrika Hofling, Gonzalo Hijos-Mallada, Carlos Sostres, Angel Lanas
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
colorectal cancer
biomarker-based aspirin dose optimization
thromboxane A2
prostaglandin E2
cyclooxygenases
platelets
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1362217/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1362217/full

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