Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation via regulating microglia M1/M2 polarization and JAK1/STAT3 pathway

Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation via regulating microglia M1/M2 polarization and JAK1/STAT3 pathway

The present study was performed to investigate the antidepressant effect of echinacoside (ECH) using chronic unpredictable mild stress (CUMS) induced depression mice and lipopolysaccharide (LPS)-stimulated N9 microglial cells. CUMS treatment was performed on C57BL/6 mice for 28 days, followed by gav...

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Bibliographic Details
Main Authors: Renrui Lu, Li Zhang, Huihui Wang, Meng Li, Weisheng Feng, Xiaoke Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
depression
echinacoside
M1/M2 polarization
neuroinflammation
JAK1/STAT3 pathway
BDNF
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.993483/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.993483/full

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