Structure of <i>Mycobacterium tuberculosis</i> 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Structure of <i>Mycobacterium tuberculosis</i> 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Stagnation in the development of new antibiotics emphasizes the need for the discovery of drugs with novel modes of action that can tackle antibiotic resistance. Contrary to humans, most bacteria use the methylerythritol phosphate (MEP) pathway to synthesize crucial isoprenoid precursors. 1-deoxy-D-...

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Bibliographic Details
Main Authors: Victor Oliveira Gawriljuk, Rick Oerlemans, Robin M. Gierse, Riya Jotwani, Anna K. H. Hirsch, Matthew R. Groves
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Crystals
Subjects:
1-deoxy-D-xylulose 5-phosphate synthase
MEP pathway
butylacetylphosphonate
antibiotics
<i>Mycobacterium tuberculosis</i>
DXPS
Online Access:https://www.mdpi.com/2073-4352/13/5/737

Internet

https://www.mdpi.com/2073-4352/13/5/737

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